Trial Attorney and Pharmaceutical Litigation Expert, Serious muscle damage that can harm the kidneys, Blood vessels burst and bleed around the brain, Testing Positive for COVID-19: It Felt Like I Had a Compression Belt Around My Chest, COVID-19: A Consumer’s Guide to the Coronavirus, Status of Bard, Ethicon and Atrium Hernia Mesh Lawsuits, Erika Sward of American Lung Association Reveals the Dangers of Vaping and IQOS, Triple Heart Attack Victim: ‘Crestor Almost Killed Me’, This article contains incorrect information, This article doesn't have the information I'm looking for, https://www.accessdata.fda.gov/drugsatfda_docs/label/2018/021366s038lbl.pdf, https://www.fda.gov/drugs/postmarket-drug-safety-information-patients-and-providers/rosuvastatin-calcium-marketed-crestor-information, https://jamanetwork.com/journals/jama/article-abstract/2584061, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3303484/, https://www.crestor.com/crestor-side-effects.html, https://www.ncbi.nlm.nih.gov/pubmed/22001973, https://www.ajmc.com/journals/supplement/2004/2004-11-vol10-n3preventivemedicine/nov04-1971ps030-s037, https://medlineplus.gov/ency/article/000473.htm, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4006404/, https://www.medpagetoday.org/cardiology/dyslipidemia/1093?vpass=1, https://www.ahajournals.org/doi/full/10.1161/circulationaha.105.555482, https://www.thelancet.com/journals/lancet/article/PIIS0140-6736%2804%2916513-6/fulltext, http://www.washingtonpost.com/wp-dyn/articles/A2787-2005Mar2.html, https://www.citizen.org/article/letter-demonstrating-that-rosuvastatin-crestor-has-higher-rates-of-rhabdomyolysis-compared-to-other-statins/, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3983981/, https://www.ncbi.nlm.nih.gov/books/NBK548620/, https://www.medscape.com/viewarticle/769024?pa=mcx5JvCyQx3QyO2lA13c1jl%2BPAkWNZ1veTw4em5pa8cZhza5pEO20kHYJlh37jtAJyGvMX%2Fu%2BWdIXoARf%2FT0zw%3D%3D, https://care.diabetesjournals.org/content/36/7/e100, https://www.nejm.org/doi/full/10.1056/NEJMoa0807646, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4360430/, https://www.stroke.org/en/about-stroke/types-of-stroke/hemorrhagic-strokes-bleeds, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4747071/, https://www.nejm.org/doi/pdf/10.1056/NEJMoa061894, https://www.ahajournals.org/doi/pdf/10.1161/strokeaha.112.655894, https://www.clinicalcorrelations.org/2014/05/14/new-cholesterol-guidelines-how-safe-are-high-potency-statins/, https://www.fda.gov/drugs/drug-safety-and-availability/fda-drug-safety-communication-important-safety-label-changes-cholesterol-lowering-statin-drugs, https://www.health.harvard.edu/cholesterol/new-findings-on-statin-memory-loss-link, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2651637/, https://www.health.harvard.edu/heart-health/statin-side-effects-how-common-are-they, FDA. Statins can raise the levels of liver enzymes called serum alanine aminotransferase (ALT). JUPITER Analysis Helps Assuage Fears About Diabetes Risk with Statins. As blood carrying myoglobin passes through the organs, it can cause serious problems including kidney failure. Retrieved, Alsheikh-Ali, A.A. et al. Statin Use and Risk of Diabetes Mellitus. Warning signs of rhabdomyolysis include muscle aches and dark-colored urine. Patients with kidney impairment are also at an increased risk for myalgia. The condition is considered rare. FDA Drug Safety Communication: Important Safety Label Changes to Cholesterol-Lowering Drugs. Prior results do not predict a similar outcome. In 2005, a study in the American Heart Association journal Circulation found patients taking Crestor were eight times more likely to develop rhabdomyolysis, renal failure or proteinuria — high levels of protein in the urine — than patients taking certain other statins. ALERT: Your health is top priority. The agency believed other statins already on the market had a similar rate of rhabdomyolysis. (2012, August). At the time, the agency knew about cases of rhabdomyolysis during Crestor’s premarketing trials. If you found our resources and information helpful, please take a minute to review us on Facebook and Google. Letter Demonstrating that Rosuvastatin (Crestor) Has Higher Rates of Rhabdomyolysis Compared to Other Statins. We appreciate your feedback. Rhabdomyolysis is a rare form of muscle damage that can lead to severe kidney injury or failure. (2013, July). Crestor’s label carries a warning about skeletal muscle effects. But statins may increase the risk of hemorrhagic strokes. (n.d.). They found people taking the medicine were nearly four times more likely to report memory loss within 30 days after starting the drug. Statin-Induced Rhabdomyolysis: A Comprehensive Review of Case Reports. (2005, March 10). Retrieved, Mendes, P. et al. How Long Does Coronavirus Live On Surfaces? Magazine, R. and Bairy, K.L. It tells health care professionals to advise patients to “report unexplained muscle pain, tenderness, or weakness.” The warning mentions myopathy and rhabdomyolysis specifically. Drug Record; Rosuvastatin. et al. Retrieved, NIH. In 2015, researchers compared people who took any type of cholesterol medicine with those who didn’t. As are patients taking cyclosporine, atazanavir/ritonavir, lopinavir/ritonavir or simeprevir. Rosuvastatin Calcium (Marketed as Crestor) Information. Studies have shown taking statins may increase a person’s risk of developing diabetes by 9 to 48 percent. Side Effects of Crestor. Retrieved, Tomaszewski, M. (2011). But in the drug’s first year, the number of rhabdomyolysis cases among Crestor users was higher than for other statins. Memory impairment may be reversible by temporarily discontinuing Crestor. New Cholesterol Guidelines: How Safe Are High-Potency Statins? All rights reserved. These symptoms include feeling tired or weak, pain in the upper belly, skin yellowing, dark urine and yellowing of the whites of the eyes. © 2020 Drugwatch.com Privacy Policy/ Calling this number connects you with a Drugwatch representative. Crestor’s side effects range from common, relatively mild reactions such as headaches to a rare, severe condition called rhabdomyolysis, which has been linked to kidney damage and death. (2015, July 10). CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals. New Findings on Statin-Memory Loss Link. (2012, February 1). (n.d.) Rhabdomyolysis. Crestor’s label says the conditions can happen at any time after taking Crestor. Generalized Weakness 2. (2013, September). Myoglobin is harmful to the kidneys. Crestor prevents recurrence of ischemic stroke. Cases of cognitive impairment have been reported in patients using Crestor and other statins. Retrieved, Ridker, P.M. et al. Selected from data included with permission and copyrighted by First Databank, Inc. Effect and Safety of Rosuvastatin in Acute Ischemic Stroke. Serious liver damage occurs in about less than 1 percent. Retrieved, Liao, J.K. (2006, December 15). Keep people safe from potentially harmful drugs, medical devices and procedures by informing them of medical conditions, severe side effects and ways to take action. (2014, April 25). et al. Hemorrhagic Stroke. Drugwatch's sponsors support the organization's mission to keep people safe from dangerous drugs and medical devices. Your chances of getting muscle problems are higher if you: Retrieved, Anderson, M. (2014, May 14). Retrieved, FDA. Crestor may also increase the chances of liver damage and diabetes. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment. Rhabdomyolysis causes skeletal muscle tissue to break down rapidly and travel into the bloodstream. This will help our consumer safety information reach more people. Join our newsletter to stay up to date on dangerous drugs and devices, keep up on lawsuit and settlement news, learn about FDA recalls, and more. Safety and Efficacy of Statins in Asians. Myopathy is a group of disorders in which muscle fibers do not function properly. Please seek the advice of a medical professional before making health care decisions. The agency based its decision on studies and adverse event reports. This drug is associated with several possible common side effects. Retrieved, Harvard Medical School. Crestor Label.