The AHA says that high-quality evidence from large randomized controlled trials have shown that statins are effective at bringing LDL levels and heart risks down. Click here to sign in with "We have some evidence that there is a link between statins, physical activity and the GILZ protein, and our plan is to shed more light on how these factors interact with each other," says Professor Kiemer. The researchers said the review of 35 randomized controlled trials failed to show a consistent benefit in lowering the risk of heart attack or stroke, or for preventing deaths. Visit BBC News for up-to-the-minute news, breaking news, video, audio and feature stories. "I think it's a decision between a patient and a provider," he said. But Lloyd-Jones wasn't convinced by the research. If you have questions or concerns about cholesterol medications, there are better-designed studies to answer these questions. Neither your address nor the recipient's address will be used for any other purpose. Read Newsmax Terms and Conditions of Service. The precise nature of the bodily processes that induce symptoms of muscle impairment has not yet been fully characterized. We tried to objectively look at all of the evidence, not just those studies we favored," DuBroff said. "The acronym GILZ stands for glucocorticoid-induced leucine zipper," explains Professor Kiemer. "When we look at what happens when statins are administered to muscle cells or entire muscle fibres in which GILZ has been genetically deactivated, the damage that was previously observed is now almost completely absent," says Kiemer. But we're not the first to raise these concerns. "It's a leap of faith to think that if you lower LDL, it will bring down your cardiovascular risk and mortality. "I don't think the review's conclusions are supported by science. Five reported a reduction in heart attacks and strokes. Support us. May 29, 2020. "This is not like an antibiotic where you can treat for a week and then stop," he said. "Statins are very effective at lowering LDL cholesterol [preventing it from developing into plaque that deposits on blood vessel walls]. He noted that most experts agree that LDL cholesterol plays a critical role in the development of plaques that stiffen blood vessels. This, however, leads to impaired muscle function, because increased GILZ production results in an increased rate of muscle cell death. Hundreds of millions of people worldwide take cholesterol-lowering drugs, like statins, but now a new review suggests that many folks don't benefit from these medications. While the American Heart Association also emphasizes the importance of a healthy lifestyle, the heart group also recommends that certain people take cholesterol-lowering medications. DuBroff said he thinks the guidelines for using cholesterol-lowering medicines may "need to revisit some of this negative or contradictory evidence. A recent study – the longest ever into statins - carried out by scientists at Imperial College, London, and the University of Glasgow, (published in September 2017), produced interesting results. Inherited high cholesterol may be common in people with heart disease . Older patients and female patients appear to be at greater risk of developing these symptoms, but so too are patients that are very physically active," explains Alexandra K. Kiemer, Professor of Pharmaceutical Biology at Saarland University. Patients who take statins in order to lower their blood cholesterol levels often complain about muscle problems, typically muscle pain. More information: Jessica Hoppstädter et al, The glucocorticoid‐induced leucine zipper mediates statin‐induced muscle damage, The FASEB Journal (2020… "Normally, when you have a theory that says something is beneficial, it should be beneficial all the time, but not all of these studies show the benefit," said study author Dr. Robert DuBroff. part may be reproduced without the written permission. The pharmaceutical researchers led by Alexandra K. Kiemer are therefore planning a new study to be conducted in collaboration with the sports medicine physician Anne Hecksteden from the research group headed by Professor Tim Meyer at Saarland University. However, that's where DuBroff diverges from the American Heart Association and the American College of Cardiology. The information presented on this website is not intended as specific medical advice and is not a substitute for professional medical treatment or diagnosis. Alexandra K. Kiemer and her research group may now have identified the actual cause of the muscle pain affecting patients receiving statins. SpaceX launches 4 astronauts to space station, beginning new era for NASA. It's Cholesterol Education Month, a good time to protect your health by sorting out the sometimes-confusing facts. They are also inexpensive. The study has been published in The FASEB Journal under the title "The Glucocorticoid-Induced Leucine Zipper Mediates Statin-Induced Muscle Damage.". Furthermore, the statins appear to impair the success of physical training programmes. The content is provided for information purposes only. Nasa, Boeing, Bezos and Musk have a lot riding on the US election. LDL is just one component of the cardiovascular disease process," he said, adding that just correcting LDL may not be enough to make a difference in the risk of heart disease, stroke and death. Categories: Cholesterol | Tags: Cholesterol, Food & Nutrition News, Prevention. By using our site, you acknowledge that you have read and understand our Privacy Policy Hundreds of millions of people worldwide take cholesterol-lowering drugs, like statins, but now a new review suggests that many folks don't benefit from these medications. While the latest research first looked at 35 randomized controlled trials of cholesterol-lowering drugs, only 13 of the studies lowered LDL (the "bad" cholesterol) levels enough to be included in the review.